The aim of EVI-GENORET is to build on our understanding of the fundamental molecular
and cellular biology of the retina, of its development and the way it is perturbed by
genetic mutation, environmental factors and age.To gather and integrate the information on gene function brought about by the numerous human, animal and in vitro models of retinal development and degeneration available. To standardize and analyze this information (databases and expression studies) To validate the information (functional assays and models) To facilitate the design of genomic-based therapy that would obviously potentially benefit patients but also validate the pathways and targets identified using the above-described approaches. The goal at the completion of the program would be to help integrate a broad and in depth understanding of the function and interactions of major cells and genes networks, thereby proposing functional models. The key questions and issues faced in addressing these questions are:
2) Analyze the information: Functional genomic tools 3) Validate the information 4) Design genomic-based therapy |